Work Package 3 - Survival associated with Congenital Anomalies
To expand the knowledge on the survival of children born with congenital anomalies for the first 10 years of life and to evaluate prenatal diagnosis and other risk factors for survival in Europe.
Description of Work and Role of Partners
This WP will be led by Prof. Judith Rankin (UNEW) and Dr. Anna Pierini (CNR-IFC)
The specific tasks are to:
- Evaluate the survival of babies with specific congenital anomalies and by selected EUROCAT congenital anomaly
subgroups across Europe (UNEW)
- Investigate whether survival of infants and children is associated with occurrence of a prenatal diagnosis (UNEW)
- Investigate whether there are geographic variations in survival across Europe for specific congenital anomaly
- Investigate the association of risk factors (gender, birth weight, gestation length, maternal age, parity, socio-economic
status, non-European origin of the parents) and survival (UNEW). For each task the lead partners (UNEW, CNR-IFC) will be responsible for completing literature reviews on the topic, designing study protocols, organising subgroup meetings, receiving data from WP2 Central Results Repository, analysing data and writing final reports/scientific papers. Each partner/registry is responsible for performing local analyses and aggregating the data, sending the results to the Central Results Repository, and taking part in discussion of results and commenting on drafts of each paper. Analysis will focus on some EUROCAT subgroups of specific congenital anomalies (for example spina bifida, Tetralogy of Fallot, oro-facial clefts, esophageal atresia, small intestinal atresia/stenosis, anorectal atresia, bladder extrophy, diaphragmatic hernia, omphalocele, gastroschisis and certain syndromes).