WP3 Deliverable D3.2: Report on geographical variations in Europe on survival of children born with a congenital anomaly
Authors: Anna Pierini, Alessio Coi, Michele Santoro, Judith Rankin, Svetlana Glinianaia, Maria Loane, Joanne Given, Joachim Tan, Abigail Reid, Joan Morris
Contributing participants and partners (in Beneficiary numerical order): Joachim Tan, Abigail Reid, Gillian Briggs, Joan Morris (SGUL), Kari Klungsøyr (Norway), Miriam Gatt (Malta), Maria Loane, Joanne Given, Katy Karnell (UU), Ester Garne, Stine Kjær Urhøj (RSD), Svetlana Glinianaia, Judith Rankin (UNEW), Amanda Neville, Gianni Astolfi, Aurora Puccini, Annarita Armaroli (UNIFE), Ingeborg Barišic, Ljubica Odak (KDB), Anna Pierini, Alessio Coi, Michele Santoro (CNR-IFC), Hermien de Walle, Renée Lutke, Nicole Siemensma Mühlenberg (UMCG), David Tucker, Daniel Thayer, Ieuan Scanlon, Ting Wang, Sue Jordan (PHW NHS, SU), Babak Khoshnood, Nathalie Lelong, Nathalie Bertille (INSERM), Clara Cavero Carbonell, Sandra Moreno Marro, Laia Barrachina Bonet (FISABIO), Mika Gissler, Anna Heino, Sonja Kiuru-Kuhlefelt, Tuuli Puroharju (THL), Wladimir Wertelecki, Lyubov Yevtushok, Lyubov Ostapchuk, Diana Akhmedzhanova (OMNI NET), Anke Rissmann, Dorit Goetz (OVGU), Vera Nelen, Guy Thys, Carmen Franken, Elly Den Hond (PIH), Olatz Mokoroa Carollo (BIOEF), James Densem (BIOMED)
Lay summary:
This part of the EUROlinkCAT project analysed the survival of children with a range of different congenital anomalies during their first 10 years of life and investigated some maternal and infant characteristics known to be associated with survival. Geographical differences on survival of children born with a congenital anomaly were also investigated. Fourteen population-based European registries, part of the European Surveillance of Congenital Anomalies (EUROCAT) network, successfully linked their congenital anomaly live birth cases to the local mortality records or national/vital statistics. We found that survival of children born in the last decade (2005-2014) improved in almost all European regions. Survival at 5 years ranged from 87%-98% across European regions but there was no clear geographical pattern. Geographical differences in survival were not explained by common risk factors, although we found that birthweight was moderately associated with survival. Survival in children with congenital anomalies was higher in areas where children in the general population had higher survival.
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