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WP4 Deliverable D4.2: Report on infections and use of antibiotics during the first 5 years of life

Authors: Maria Loane, Leke Aminkeng, Joanne Given, Ester Garne, Mads Damkjaer, Gillian Briggs, Joan Morris

Contributing participants and partners (in Beneficiary numerical order): Joachim Tan, Abigail Reid, Gillian Briggs, Elizabeth Limb, Hugh Claridge, Joan Morris (SGUL), Maria Loane, Joanne Given, Katy Karnell, Leke Aminkeng, Jailos Lubinda, Natalie Divin (UU), Ester Garne, Stine Kjaer Urhoj, Mads Damkjær (RSD), Amanda Neville, Gianni Astolfi, Aurora Puccini, Annarita Armaroli (UNIFE), Anna Pierini, Alessio Coi, Michele Santoro, Silvia Baldacci (CNR-IFC), Hermien de Walle, Renée Lutke, Nicole Siemensma-Mühlenberg (UMCG), David Tucker, Daniel Thayer, Ieuan Scanlon, Sue Jordan (PHW NHS, SU), Clara Cavero Carbonell, Óscar Zurriaga, Sandra Moreno Marro, Laia Barrachina Bonet, Laura García Villodre (FISABIO), Mika Gissler, Anna Heino, Sonja Kiuru-Kuhlefelt, Tuuli Puroharju (THL)

Lay Summary:
Little is known about antibiotic use in children with congenital anomalies. This study addresses this question by examining the number of antibiotic prescriptions in children up to five years of age with congenital anomalies compared to the number of antibiotic prescriptions in children without congenital anomalies.

Seven European congenital anomaly registries, which are part of the European Surveillance of Congenital Anomalies network (EUROCAT), successfully linked records of children born between 2000 and 2014 with and without congenital anomalies, to their local electronic prescription databases.

Our preliminary results show that a greater proportion of children with congenital anomalies were prescribed/dispensed antibiotics and were prescribed more antibiotics compared to children without congenital anomalies. We also found that children under one year of age had more antibiotics compared to children aged between 1 and 4 years of age. We are continuing to analyse these data in greater detail. This information is important for parents of children with congenital anomalies.

Click here for a PDF of the report