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WP4 Deliverable D4.3: Report on prenatal diagnosis and morbidity

Authors: Mika Gissler, Anna Heino, Sonja Kiuru-Kuhlefelt, Joan Morris, Ester Garne

Contributing participants and partners (in Beneficiary numerical order): Joachim Tan, Abigail Reid, Hugh Claridge, Joan Morris (SGUL), Diana Wellesley (WANDA), Maria Loane, Joanne Given, Katy Karnell, Jailos Lubinda (UU), Ester Garne, Stine Kjaer Urhoj, Mads Damkjær (RSD), Amanda Neville, Gianni Astolfi, Aurora Puccini, Annarita Armaroli, Cecilia Martellucci (UNIFE), Ingeborg Barišic, Ljubica Odak (KDB), Anna Pierini, Alessio Coi, Michele Santoro, Silvia Baldacci (CNR-IFC), Hermien de Walle, Renée Lutke, Nicole Siemensma-Mühlenberg, Marian Bakker (UMCG), David Tucker, Daniel Thayer, Ieuan Scanlon, Sue Jordan (PHW NHS, SU), Clara Cavero Carbonell, Óscar Zurriaga, Sandra Moreno Marro, Laia Barrachina Bonet, Laura García Villodre (FISABIO), Mika Gissler, Anna Heino, Sonja Kiuru-Kuhlefelt (THL)

Lay Summary:

In this part of the EUROlinkCAT project, we analysed the health-related data of children born with a congenital anomaly detected during the pregnancy compared with children whose congenital anomaly was found at birth or later. The analyses were limited to children with four specific congenital anomalies: spina bifida, transposition of great arteries, congenital diaphragmatic hernia and gastroschisis. Eleven European congenital anomaly registries, which are part of the European Surveillance of Congenital Anomalies network (EUROCAT), successfully linked their records of children with congenital anomalies to records held by hospital databases. Our analysis found that children with prenatally detected congenital anomalies were more likely to be admitted to hospital and once there had longer hospital stays than children with congenital anomalies diagnosed at or after birth. One explanation may be that the cases detected prenatally are more severe than those diagnosed later and thus require more hospital treatment. Prenatal detection of congenital anomalies is important, since it enables the best place and mode of delivery to be chosen as well as ensuring that treatment after birth is available in a specialised unit.

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